References

A decade of HPAE gene delivery research.

Selected publications supporting highly branched poly(β-amino ester) gene delivery, non-viral delivery, CRISPR delivery, skin/lung gene therapy and biomedical polymer applications.

2025

1 publication
  • Guanidyl-rich highly branched poly(β-amino ester)s for delivery of dual CRISPR ribonucleoprotein for large DNA fragment deletion

2024

4 publications
  • Highly branched poly β-amino ester / CpG-depleted CFTR plasmid nanoparticles for non-viral gene therapy in lung cystic fibrosis

  • Nonviral CRISPR/Cas9 mutagenesis for streamlined generation of mouse lung cancer models

  • Cyclization-Enhanced Poly(β-Amino Ester)s Vectors for Efficient CRISPR Gene Editing Therapy

  • Backbone Cationized Highly Branched Poly(β-Amino Ester)s as Enhanced Delivery Vectors in Non-Viral Gene Therapy

2023

7 publications
  • CRISPR/Cas9 Non-viral Gene Editing Therapy for Topical Treatment of Recessive Dystrophic Epidermolysis Bullosa

  • Guanidyl-Rich Poly(Amino Ester)s for Universal Cytosolic Protein Delivery and CRISPR Cas9 RNP-Based Gene Editing

  • Enhanced gene transfection efficacy and safety through granular hydrogel mediated gene delivery process

  • 3D Macrocyclic Structure Boosted Gene Delivery: Multi-cyclic Poly(β-Amino Ester)s from Step Growth Polymerization

  • Branch Unit Distribution Matters for Gene Delivery

  • A New Optimization Strategy of Highly Branched Poly(β-Amino Ester) for Enhanced Gene Delivery

  • Highly branched poly(β-amino ester)s with narrow molecular weight distribution: fractionation and gene transfection activity

2021

2 publications
  • Highly Branched Poly(β-amino ester)s for Gene Delivery in Hereditary Skin Diseases

  • Non-viral delivery of CRISPR–Cas9 complexes for targeted gene editing via a polymer delivery system

2020

1 publication
  • Effects of Branching Strategy on the Gene Transfection of Highly Branched Poly(β-amino ester)s

2019

2 publications
  • Efficient and Robust Highly Branched Poly(β-Amino Ester) Minicircle COL7A1 Nanoparticles for RDEB Keratinocytes

  • Highly branched poly(β-amino ester) delivery of minicircle DNA for neurodegenerative disease cells

2018

1 publication
  • Multifunctional Linear-Branched Hybrid Poly(β-Amino Ester) via Oligomer Combination Approach

2017

4 publications
  • Brushlike Cationic Polymers with Low Charge Density for Gene Delivery

  • Star poly(β-amino esters) from the Combination of Linear PBAE and Polyethyleneimine

  • Highly Branched poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) for High Performance Gene Transfection

  • Thermo- and pH-Responsive Coacervate-Forming Hyperbranched Poly(β-amino ester)s for Selective Cell Binding

2016

5 publications
  • Highly Branched Poly(β-amino ester)s for Skin Gene Therapy

  • Biodegradable Highly Branched Poly(β-amino ester)s for Targeted Cancer Cell Gene Transfection

  • A non-viral gene therapy for treatment of recessive dystrophic epidermolysis bullosa

  • Highly Branched Poly(β-amino esters) for Non-Viral Gene Delivery: high transfection efficiency and low toxicity

  • The Transition from Linear to Highly Branched Poly(β-amino ester)s: Branching Matters

2015

1 publication
  • Tailoring highly branched poly(β-amino ester)s: a synthetic platform for epidermal gene therapy

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